Panchenko found her true calling by becoming a fashion designer. She created sketches of clothes, decorative paintings, fabric applications, graphics, and paintings. The embroidery designs by Lyubov Panchenko were published by the main women's magazine of Ukraine at the time, "Soviet Woman." These patterns were then copied by masters throughout the country.
She always supported the Ukrainian language and culture. Panchenko painted pysanky (easter eggs), embroidered national costumes for choirs, and raised money to help political prisoners serving sentences for "Anti-Soviet Agitation and Propaganda." With her participation, the tradition of Christmas caroling and Ukrainian vertep (nativity scene) was revived in Kyiv.
In 1964, Alla Horska, Lyudmyla Semykina, and Halyna Sevruk created a stained glass window "Shevchenko. Mother" at the Kyiv University. Around the same time, Panchenko made sketches of Ukrainian "rushnyk" (towels embroidered with national symbols) and decorated the walls of the Taras Shevchenko Museum in Kyiv.